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侯智尧,1980年8月出生,广州医科大学病理学与病理生理学教授,博士研究生导师,广州市高层次人才。现任中国稀土学会稀土晶体专业委员会委员、《发光学报》青年编委、担任Adv. Mater., ACS Nano, Adv. Sci., Nano Letters, Biomaterials等国际期刊审稿人。以负责人身份承担国家自然科学基金项目5项,地方级科研项目4项,2014年分别获得吉林省科学技术奖一等奖和吉林省自然科学学术成果奖一等奖。
研究方向:侯智尧教授针对光能转换材料合成与应用中的基本科学问题,以半导体电子跃迁和稀土纳米晶离子能量传递为理论基础,结合医学、生物学、材料学和化学等多学科交叉的研究优势,开展新型纳米光能转换材料构建及其在肿瘤光学诊疗中应用的基础研究,实现了多模态影像导航下的近红外光响应抗肿瘤协同治疗,同时结合肿瘤治疗临床标准开展肿瘤微环境响应的温度可控的光热治疗。目前在Adv. Mater.、Angew. Chem. Int. Ed.、ACS Nano、Adv. Funct. Mater.、Small、Biomaterials等国际学术期刊上发表SCI论文128篇,论文被他人引用超过10000次,H-index指数为59,其中第一/通讯作者论文45篇(ESI高被引论文4篇)。
近年主持科研项目
(1)国家自然科学基金面上项目,52072082,可分解的碳酸钙包覆氧化亚铜纳米复合材料用于结直肠肿瘤微环境触发的多模态协同治疗,2021/01-2024/12,58万元,在研,主持;
(2)国家自然科学基金面上项目,51672268,多功能羟基磷灰石纳米晶的控制合成及其在活性组织工程骨构建中的应用,2017/01-2020/12,62万元,已结题,主持;
(3)国家自然科学基金面上项目,51472233,二氧化钛/稀土上转换发光纳米复合材料的合成及其近红外光响应光动力疗法抗肿瘤作用的研究,2015/01-2018/12,83万元,已结题,主持;
(4)国家自然科学基金青年项目,32101143,光学治疗激活的促吞噬纳米颗粒用于巨噬细胞介导抗肿瘤免疫治疗的研究,2022/01-2024/12,30万元,在研,主持(张亚茹);
(5)广东省普通高校重点领域专项,2020ZDZX2020,肿瘤微环境响应的智能光热治疗剂制备及其近红外光诱导的肿瘤光热治疗研究,2021/01-2023/12,15万元,在研,主持;
(6)广东省自然科学基金面上项目,2019A1515012214,近红外光抑制阿尔兹海默症致病Tau蛋白聚集及机制研究,2019/10-2022/09,10万元,在研,主持;
(7)清远市人民医院开放课题重大项目,202011-105,结直肠肿瘤微环境响应的抗肿瘤光热治疗,2020/12-2023/11,100万元,在研,主持。
近年主要发表论文
(1) Man Wang M, Mengyu Chang, Chunxia Li*, Qing Chen,Zhiyao Hou*, Bengang Xing, Jun Lin*, Tumor Microenvironment-activated Reactive Oxygen Species Amplifier for Enzymatic Cascade Cancer Starvation/Chemodynamic/Immunotherapy,Adv. Mater., 2022, 34(4), 2106010.(IF:30.849)
(2) Mengyu Chang,Zhiyao Hou*, Man Wang, Chunxia Li, Jun Lin*, Recent Advances in Hyperthermia Therapy-Based Synergistic Immunotherapy,Adv. Mater.,2021, 33(4), 2004788.(IF:30.849)
(3)Mengyu Chang,Zhiyao Hou*, Dayong Jin*, Jiajia Zhou, Man Wang, Meifang Wang, Mengmeng Shu, Binbin Ding, Chunxia Li, Jun Lin*, Colorectal Tumor Microenvironment‐Activated Bio‐Decomposable and Metabolizable Cu2O@CaCO3Nanocomposites for Synergistic Oncotherapy,Adv. Mater., 2020, 32(43), 2004647.(IF:30.849)
(4)Mengyu Chang, Man Wang, Meifang Wang, Mengmeng Shu, Binbin Ding, Chunxia Li, Maolin Pang, Shuzhong Cui,Zhiyao Hou*, Jun Lin*, A Multifunctional Cascade Bioreactor Based on Hollow Structured Cu2MoS4for Synergetic Cancer Chemo-Dynamic Therapy/Starvation Therapy/Phototherapy/Immunotherapy with Remarkably Enhanced Efficacy,Adv. Mater., 2019, 31(51), 1905271.(IF:30.849, ESI高被引论文)
(5)MeiFang Wang, Kerong Deng, Wei Lü, Xiaoran Deng, Kai Li, Yanshu Shi, Binbin Ding, Ziyong Cheng,Zhiyao Hou*, Jun Lin*,Rational Design of Multifunctional Fe@γ-Fe2O3@H-TiO2Nanocomposites with Enhanced Magnetic and Photoconversion Effects for Wide Applications: from Photocatalysis to Imaging-guided Photothermal Cancer Therapy,Adv. Mater., 2018, 30(13), 1706747.(IF:30.849)
(6)Mengyu Chang,Zhiyao Hou*, Man Wang, Chunzheng Yang, Ruifeng Wang, Fang Li, Donglian Liu, Tieli Peng, Chunxia Li*, Jun Lin*, Single Atom Pd Nanozyme for Ferroptosis-Boosted Mild-Temperature Photothermal Therapy,Angew.Chem. Inter. Ed., 2021, 60(23), 12971–12979.(IF:15.336, ESI高被引论文)
(7) Meifang Wang,Zhiyao Hou*, Saina Liu, Shuang Liang, Binbin Ding, Yajie Zhao, Mengyu Chang, Gang Han, Abdulaziz A. Al Kheraif, Jun Lin*, A Multifunctional Nanovaccine based on L-Arginine-Loaded Black Mesoporous Titania: Ultrasound-Triggered Synergistic Cancer Sonodynamic Therapy/Gas Therapy/Immunotherapy with Remarkably Enhanced Efficacy,Small, 2021, 17(6), 2005728.(IF:13.281)
(8)Man Wang, Mengyu Chang, Qing Chen, Dongmei Wang, Chunxia Li*,Zhiyao Hou*, Jin Lin*, Dayong Jin, Bengang Xing, Au2Pt-PEG-Ce6 Nanoformulation with Dual Nanozyme Activities for Synergistic Chemodynamic Therapy/Phototherapy,Biomaterials, 2020, 252, 120093.(IF:12.479, ESI高被引论文)